As the main mediators of intercellular communication, extracellular vesicles carry biomolecules such as proteins, lipids, and RNAs between cells and constitue a biological vector. In addition to these natural transfer properties, extracellular vesicles may be engineered to display exogenous properties. The possibility of customizing extracellular surface or cargo has opened up a wide range of perspectives for drug delivery. As a natural product, extracellular vesicles offer several advantages such as specifity (cellular recognition and internalization and able to deliver the cargo to specific distal cell), safety (low immune response) and stability . Extracellular vesicles as delivery systems have been already used to encapsulate siRNAs, miRNAs, drugs, radiotracers and inorganic nanoparticles in animal models [2,3,4].